Zöliakie ist eine absolute Glutenunverträglichkeit und wird heute als schwerwiegende Krankheit angesehen.
Glutensensitivität wird landläufig als Unverträglichkeit verharmlost. Der folgende Fachartikel versucht diese Missverständnisse und Unkenntnisse aufzuklären:
The Many Heads of Gluten Sensitivity
[Autor:Dr. Peter Osborne,Gluten Free Society, Fri, 11 Mar 2011 06:37 CST, sott.net]
Unfortunately, today most people do not understand the difference between gluten sensitivity and celiac disease. As a matter of fact, this is one of the reasons why so many
patients fail to get properly diagnosed. Lab tests have traditionally focused on diagnosing celiac disease. This has created a proverbial No Man's Land for those patients who react to gluten
differently. Because the labs come back negative for them, they are told to continue the consumption of grains, and they are told not to worry about gluten because they don't have celiac
Until last year, most doctors and celiac disease researchers ignored or denied the existence of gluten sensitivity. The general thought was - if you don't have celiac disease, you don't have to
worry about avoiding grains.
A new study published this week attempted to elucidate the differences between Celiac
Disease and Gluten Sensitivity
As much as I love the work being done by Dr. Fasano at the University of Maryland, I have to take offense at the following quote from from Fox News' interpretation of the study:
Unlike celiac disease, gluten sensitivity is not associated with these serious conditions (referring to - autoimmune, cancer, osteoporosis, infertility, and neurological disease). Common symptoms
of gluten sensitivity include abdominal pain similar to irritable bowel syndrome, fatigue, headaches, "foggy mind" or tingling of the extremities.
The quote minimizes just how serious and life threatening gluten sensitivity is. I have personally seen non celiac gluten sensitivity cause kidney failure, liver damage, cancer,
autoimmune disease, and more. The vast majority of these patients did not have celiac disease, but did have gluten sensitivity.
I have personally interviewed many colleagues who share similar experiences with gluten sensitivity. So the question I have to ask is - Why does the media try to minimize the symptoms and
diseases associated with non celiac gluten sensitivity?
Dr. Fasano's Explanation of What Happens to Those Who Eat Gluten:
"Imagine gluten ingestion on a spectrum. At one end, you have people with celiac disease, who cannot tolerate one crumb of gluten in their diet. At the other end, you have the lucky people who
can eat pizza, beer, pasta and cookies - and have no ill effects whatsoever. In the middle, there is this murky area of gluten reactions, including gluten sensitivity. This is where we are
looking for answers about how to best diagnose and treat this recently identified group of gluten-sensitive individuals."
Dr. Fasano's team is trying to figure out the exact disease triggering mechanisms that occur when gluten is ingested. This new study shows that there are multiple mechanisms at work (more to come
on this in future posts). Some are adaptive immune responses, some are innate, some are indirect immune responses, and some on non-immune mediated responses.
Dr. Osborne's Explanation Can be Summarized in two Images
All that being said, Thank you Dr. Fasano, et al. for taking on such a complex issue. The work your team is doing continues to discover new elements of this perplexing process thus allowing
clinicians across the country to provide more up to date treatment and education of patients.
Now That the Proverbial Cat is out of the Bag, Why all the Previous Confusion?
Gluten sensitivity manifests in hundreds of different ways. It has been called a multi headed HYDRA of disease. Each head representing a different symptom or disease. (For those of you who don't
know what a Hydra is - look at the picture above) Drugs are typically used to treat the symptoms of gluten induced disease, but unfortunately, they do not correct the core of the problem. So for
every symptom a medication is used to treat, several new symptoms arise. (a Hydra will sprout two new heads for every head lost) Thus a person goes undiagnosed for years because doctors are
chasing symptoms instead of addressing their root cause.
Because research has shown that as many as 40% of all Americans may be gluten sensitive, and that 1 in 100 have a severe form of this sensitivity causing the the autoimmune intestinal disease,
celiac sprue, a case can be made that everyone in America should be screened for gluten sensitivity.
However, there are people with various risk factors or diseases that are at greater risk of having gluten sensitivity who should undoubtedly be tested.
These conditions include:
- Microscopic colitis (inflammation of the colon)
- Relatives of those with celiac disease or gluten-sensitive individuals including
- Chronic diarrhea of unknown origin
- Irritable bowel syndrome (IBS)
- Inflammatory bowel disease
- Gastroesophageal reflux disease (GERD)
- Hepatitis C
- Liver disease of unknown origin
- Dermatitis herpetiformis
- Diabetes mellitus
- Degenerative disc disease
- Colon Cancer
- Thyroid disease
- Any autoimmune diseases (common ones include):
Gluten Free Society,Fri, 29 Jan 2010 20:36 CST, sott.net
Another study links nerve damage to gluten sensitivity. Gluten has been identified as a potential neurotoxin, and many with gluten sensitivity do not manifest symptoms of classic celiac disease,
but instead develop nerve damage. In this study, the average age for nerve damage to develop was 55. A correlation was found between patients with idiopathic neuropathy (nerve damage of an
unknown cause) and the presence of gluten intolerant HLA-DQ genes.
The Gluten Free Society would like to thank the authors of this study for their continued excellent research in the field of gluten induced nerve disease. Dr. Hadjivassiliou and colleagues have
published a number of papers connecting gluten sensitivity with nerve damage. Many neurological conditions both acute and chronic are associated with gluten sensitivity. Below is a small list of
some of the more commonly known:
Carpal tunnel syndrome
Restless legs syndrome
Numbness and tingling of the hands and feet (Neuropathy)